The Notch pathway is integrated into numerous developmental processes and therefore is fine-tuned on many levels, including receptor production, endocytosis, and degradation.Notch is further characterized by a twofold relationship with its Delta-Serrate (DSL) ligands, as ligands from opposing cells (trans-ligands) activate Notch, whereas ligands ex
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide due to high recurrence rates after curative treatment and being frequently diagnosed at an advanced stage.Immune-checkpoint inhibition (ICPI) has yielded impressive clinical successes in a variety of solid cancers, however results in treatment of HCC have
The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for drug dependence and addiction.Rodent models Kindle Case indicate opposing roles of the gut microbiota in tolerance: morphine-induced gut dysbiosis exacerbates tolera
Evangelicals living in a democracy are faced with the pressures of constitutionalism and the influence of secularism.These two forces unsettle God from the public spaces and enhance decadent culture.This article addresses the current challenges Evangelicals face in the decadent culture of democracy in South Africa.The essence of the proposal is how